Flavonoids: not just for cancer anymore.
نویسنده
چکیده
Increasingly, veterinary clients are using nutraceuticals as adjuvant treatment for a variety of ailments in their pets. Recent evidence suggests that more than 50% of clients who have companion animals with cancer are using a nutraceutical and/or supplement as part of the treatment plan, and 65% of these clients say their veterinarian approves. This trend does not extend to healthy pets, of which only 10% receive routine supplements. Unfortunately, few resources regarding the safety of nutraceutical use exist, and recent evidence has shown that doses of human-formulated supplements such as lipoic acid can be toxic to cats. Veterinarians need a better understanding of the metabolism and safe upper limits for commonly used nutraceuticals because many clients are giving these products to their pets, often in human formulations. This article focuses primarily on two flavonoids: epigallocathechin-3-O-gallate (EGCG), a flavanol, and genistein, an isoflavone.
منابع مشابه
Antiproliferative effects of flavonoid fractions from Calendula officinalis flowers in parent and tamoxifen resistant T47D human breast cancer cells
The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...
متن کاملAntiproliferative effects of flavonoid fractions from Calendula officinalis flowers in parent and tamoxifen resistant T47D human breast cancer cells
The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...
متن کاملThe Cytotoxic and Synergistic Effects of Flavonoid Derivatives on Doxorubicin Cytotoxicity in Hela, MDA-MB-231, and HT-29 Cancer Cells
Background: Flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. Methods: The cytotoxic effects of three synthesized flavonoid derivatives (K3, K4 and K5) were evaluated against Hela , MDA-MB -231 and HT-29 cancer cells using MTT assay. Results: The results showed that these flavonoids were n...
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عنوان ژورنال:
- Compendium
دوره 33 10 شماره
صفحات -
تاریخ انتشار 2011